Ichiro Hisatome Selected Research

Uric Acid (Urate)

10/2023	Comparison of Recommendations Made by Committee Members with and without Financial Conflict of Interest on Japanese Guideline of Treatment of Hyperuricemia and Gout, Third Edition.
10/2023	Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases.
7/2023	Characterization of Urate Metabolism and Complications of Patients with Renal Hypouricemia.
4/2023	Impact of Hyper- and Hypo-Uricemia on Kidney Function.
4/2023	Dysuricemia-A New Concept Encompassing Hyperuricemia and Hypouricemia.
1/2023	Update in uric acid, hypertension, and cardiovascular diseases.
1/2023	Febuxostat and renal outcomes: post-hoc analysis of a randomized trial.
7/2022	Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes.
1/2022	Xanthinuria Type 1 with a Novel Mutation in Xanthine Dehydrogenase and a Normal Endothelial Function.
1/2022	Factors Influencing Change in Serum Uric Acid After Administration of the Sodium-Glucose Cotransporter 2 Inhibitor Luseogliflozin in Patients With Type 2 Diabetes Mellitus.

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Ichiro Hisatome Research Topics

Disease

30	Hyperuricemia 02/2024 - 12/2005
23	Hypertension (High Blood Pressure) 10/2023 - 09/2002
23	Heart Failure 10/2023 - 03/2002
16	Cardiovascular Diseases (Cardiovascular Disease) 10/2023 - 09/2003
12	Gout 10/2023 - 01/2010
11	Insulin Resistance 01/2021 - 03/2007
10	Ischemia 01/2018 - 09/2003
9	Chronic Renal Insufficiency 10/2023 - 12/2014
8	Myocardial Infarction 01/2023 - 08/2005
8	Hypoxia (Hypoxemia) 01/2023 - 06/2004
7	Dyslipidemias (Dyslipidemia) 03/2020 - 08/2014
6	Diabetes Mellitus 10/2023 - 09/2002
6	Inflammation (Inflammations) 10/2023 - 07/2009
6	Atrial Fibrillation 11/2019 - 08/2009
4	Renal hypouricemia 07/2023 - 01/2004
4	Non-alcoholic Fatty Liver Disease 01/2021 - 06/2010
4	Reperfusion Injury 01/2020 - 09/2003
4	Obesity 11/2017 - 06/2008
3	Kidney Diseases (Kidney Disease) 10/2023 - 01/2021
3	Atherosclerosis 10/2023 - 09/2003
3	Urolithiasis 07/2023 - 01/2022
3	Cardiac Arrhythmias (Arrythmia) 12/2022 - 11/2011
3	Thrombosis (Thrombus) 11/2020 - 11/2004
3	Left Ventricular Dysfunction 01/2018 - 09/2003
3	Long QT Syndrome 10/2016 - 02/2011
3	Disease Progression 05/2011 - 11/2004
2	Fever (Fevers) 08/2023 - 08/2002
2	Juvenile gout 06/2022 - 08/2015
2	Type 2 Diabetes Mellitus (MODY) 01/2022 - 01/2019
2	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 05/2011
2	Bradycardia 11/2019 - 01/2019
2	Colitis 10/2018 - 04/2005
2	Hepatitis 10/2018 - 03/2006
2	Dehydration (Water Stress) 01/2017 - 04/2008
2	Long Qt Syndrome 2 11/2016 - 12/2013
2	Hyperglycemia 01/2014 - 04/2008
2	Hemorrhage 04/2013 - 08/2005
2	Lung Injury 04/2013 - 04/2007
2	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 11/2011 - 12/2008
2	Thyroiditis 11/2009 - 02/2009

Drug/Important Bio-Agent (IBA)

52	Uric Acid (Urate)IBA 10/2023 - 01/2004
10	Proteins (Proteins, Gene)FDA Link 10/2023 - 07/2002
8	Febuxostat FDA Link 02/2024 - 01/2017
8	Xanthine OxidaseIBA 01/2023 - 09/2003
7	purineIBA 10/2023 - 09/2003
7	Messenger RNA (mRNA)IBA 01/2023 - 04/2007
6	Insulin (Novolin)FDA Link 01/2021 - 01/2010
6	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 06/2010
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2023 - 01/2014
5	Glucose (Dextrose)FDA LinkGeneric 01/2017 - 08/2013
4	C-Reactive ProteinIBA 10/2023 - 08/2002
4	FYX-051IBA 01/2021 - 12/2014
4	SaltsIBA 05/2020 - 04/2008
4	SodiumIBA 05/2020 - 12/2009
4	Blood Glucose (Blood Sugar)IBA 05/2020 - 11/2017
4	Antihypertensive Agents (Antihypertensives)IBA 08/2014 - 09/2002
4	CytokinesIBA 02/2014 - 01/2003
3	InflammasomesIBA 10/2023 - 11/2019
3	AlbuminsIBA 04/2023 - 12/2009
3	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2023 - 04/2005
3	Allopurinol (Remid)FDA LinkGeneric 01/2023 - 09/2003
3	HypoxanthineIBA 01/2022 - 09/2003
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2022 - 03/2002
3	Uricosuric AgentsIBA 01/2020 - 01/2010
3	AntioxidantsIBA 11/2019 - 07/2016
3	ORALIT (ORS)IBA 01/2019 - 08/2014
3	Proteasome Endopeptidase Complex (Proteasome)IBA 09/2015 - 03/2003
3	Losartan (Cozaar)FDA LinkGeneric 01/2014 - 02/2004
3	Adenosine Monophosphate (AMP)IBA 04/2013 - 09/2003
3	Inosine Monophosphate (IMP)IBA 04/2013 - 09/2003
3	RetinoidsIBA 05/2011 - 06/2010
3	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 11/2010 - 12/2002
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2010 - 01/2003
2	FructoseIBA 10/2023 - 04/2008
2	Xanthine DehydrogenaseIBA 04/2023 - 11/2019
2	Adrenergic Antagonists (Antiadrenergic Agents)IBA 01/2023 - 10/2019
2	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2023 - 08/2016
2	Carvedilol (Coreg)FDA LinkGeneric 01/2023 - 10/2019
2	UromodulinIBA 06/2022 - 08/2015
2	XanthineIBA 01/2022 - 09/2003
2	EnzymesIBA 01/2020 - 03/2006
2	cilnidipineIBA 01/2020 - 01/2012
2	Adrenergic Agents (Adrenergic Drugs)IBA 01/2019 - 01/2015
2	Angiotensin IIIBA 12/2018 - 11/2010
2	Irbesartan FDA LinkGeneric 12/2018 - 01/2014
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 09/2016 - 02/2010
2	potassium oxonateIBA 01/2016 - 05/2014
2	UbiquitinIBA 09/2015 - 12/2008
2	DiureticsIBA 02/2014 - 06/2007
2	Furosemide (Lasix)FDA LinkGeneric 02/2014 - 11/2004
2	AMP Deaminase (Myoadenylate Deaminase)IBA 04/2013 - 04/2007
2	Cardiac MyosinsIBA 11/2011 - 12/2008
2	Carrier Proteins (Binding Protein)IBA 11/2011 - 12/2008
2	NG-Nitroarginine Methyl Ester (L-NAME)IBA 05/2011 - 11/2009
2	ThioredoxinsIBA 05/2011 - 03/2006
2	CatalaseIBA 12/2010 - 03/2006
2	BenzbromaroneIBA 01/2010 - 01/2004

Therapy/Procedure

13	Therapeutics 01/2023 - 09/2003
3	Transplantation 12/2018 - 02/2013
2	Drug Therapy (Chemotherapy) 12/2022 - 10/2022